When you are doing radiometric dating, you are comparing the amount of the parent isotope to the amount of the daughter isotope. For best results, this ration should be about 1:1. That is, you want the half life to be as close as possible to the date that you are seeking. The problem with uranium-lead dating is that the long half life means that there will be very few daughter atoms after only a million years compared to the those of original parent isotope. The accuracy of the dating goes down when the ratio of these two moves away from this ratio.
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